Exclzyme-2AF Double-Strength Joint Formula


SEBbiotic® and Peptizyme SP® are registered trademarks of Specialty Enzymes and Biochemicals Co.









Exclzyme 2AF is an all-natural way to support the body’s healthy response to inflammation and promote recovery within the body.

Inflammation helps protect vulnerable organs and tissue from further damage after injury. It also initiates the chemical processes used to heal and help the body recover.

However, millions of people suffer from unhealthy, chronic inflammation, which can cause pain and swelling that never seems to end. Healthcare practitioners are increasingly convinced unhealthy inflammation is at the center of many cardiovascular, immunity, brain and joint conditions.

Exclzyme 2AF is a proteolytic (protein digesting) enzyme blend featuring Peptizyme SP brand serrapeptase.  A systemic enzyme, serrapeptase passes through the small intestine into the bloodstream purifying the body of dead cells in and around damaged tissues.  By breaking down this old cellular debris, serrapeptase improves blood circulation in the affected area, allowing vital nutrients and building blocks to nourish new cells.

Used widely for its fibrinolytic properties, research and clinical studies consistently show serrapeptase can help break down non-living tissue that is often the result of the inflammatory process. Fibrin is a protein molecule that is part of dead tissue build-up.

Exclzyme 2AF Research

More than 15 different studies have been performed on Exclzyme, including a clinical trial to observe serrapeptase’s effect on pain and inflammation. The results may affirm German doctor and atherosclerosis specialist Dr. Hans Napier claim: “Serrapeptase is the miracle enzyme.”

Studies show Exclzyme:

  • Reduces C-reactive protein levels

  • Is a natural alternative to NSAIDs

  • Improves sports injury recovery

  • Improves range of motion for people with back problems




Exclzyme vs. NSAIDS
Complete resolution in less time

Exclzyme 2AF includes serrapeptase. Studies and research demonstrate serrapeptase is effective as an all-natural, non-toxic alternative to NSAIDs (Non-Steroid Anti-Inflammatory Drugs). Many people turn to NSAIDs such as aspirin, ibuprofen, and naproxen for temporary relief, but these drugs are known to cause serious damage to the intestinal lining (ulcers), kidneys, and liver. In fact, gastrointestinal complications from prolonged NSAID use is the primary cause for emergency room visits in the United States.

Exclzyme 2AF and Joint Pain
In addition to Serrapeptase, which can block pain-inducing chemicals involved in the inflammatory response, Exclzyme 2AF contains boswellia and turmeric. These herbs are traditionally and widely known for their anti-inflammatory properties. For antioxidant support, Exclzyme 2AF contains vitamin C, amla, rutin and grape seed extract.




Enteric-Coated Serrapeptase

For the best results, serrapeptase must be enteric coated and taken on an empty stomach. If consumed in unprotected tablets or capsules, serrapeptase loses its activity in the acidic environment of the stomach. Exclzyme 2AF contains Peptizyme-SP brand serrapeptase, which is enteric-coated to ensure effective passage into the bloodstream and the rest of the body.

Double-strength, Exclzyme 2AF is specifically formulated to break down fibrin and accelerate the natural healing process.* Exclzyme 2AF is two to three times more potent than other brands on the market.

Enzyme Activity in Exclzyme®2AF Proprietary Blend


How it Works

Vitamin C

Antioxidant needed by the body for tissue growth and repair, adrenal gland function, and for healthy gums, joints, ligaments, artery walls and skin*

Vitamin B6

Also called pyroxidine; helps regulate immune function, glucose metabolism, nerve communication and homocysteine levels in the blood*


Well-known for overall bone support; also important for normal heart, nerve and muscle function, as well as proper blood clotting*


B-complex, water-soluble vitamin essential for healthy nerve function, red blood cell formation and protein metabolism; works with enzymes in the creation of new DNA*

Vitamin B12

Vital nutrient in the production of myelin, a chemical that insulates nerve cells in the transmission of neuro-electrical impulses; also has a positive effect on high homocysteine levels associated with cardiovascular disorders*

(Peptizyme SP® Brand)


Enzyme used by silkworms to digest and emerge from their silken cocoons; studied extensively for more than 50 years and found to be an excellent fibrinolytic (fibrin digesting) enzyme anti-inflammatory properties*


Hydrolyze (break-down) proteins like casein, steak, gelatin, soy, fish and other plant and animal proteins to smaller chains of polypeptides (small proteins) and amino acids for easier uptake throughout the body*


A collective name for the proteolytic (protein-digesting) enzymes found in the pineapple plant (Ananas comosus); known for its digestive properties; a good substitute for animal-based enzymes pepsin and trypsin for digestive support because of its activity across a wide pH range *


Obtained from the latex of the fruit of the Papaya tree, papain has been used for centuries as an effective digestive aid*


Breaks down carbohydrates, or more specifically, starches, into smaller dextrins and sugars; produced naturally by humans, microorganisms and plants*

Amino Peptidase

Protein-digesting enzyme with higher selectivity than other proteases*


Catalyzes the break-down of fats into essential fatty acids needed for healthy tissues and cells*


Also known as Indian gooseberry (Emblica officinalis); a natural, efficacious antioxidant, and one of the richest sources of absorbable vitamin C*


Bioflavonoid; strengthens and tones arteries and veins, and provides antioxidant support against free-radicals and inflammation*

Grapeseed Extract

Scientifically proven to be abundant in bioflavonoids, which are known for their tremendous antioxidant properties*


Native plant of India and often used in Indian herbal medicine; used extensively in Ayurvedic medicine as a useful remedy for many inflammatory conditions*


A rhizomatous herbaceous perennial plant of the ginger family; used for centuries in Ayurvedic medicine. Curcumin, its active ingredient, provides antioxidant support, inhibits blood stickiness and supports overall blood vessel integrity*

"..DigeSEB-GI, I have experienced an overall increase in energy…positive digestive experience…"

"I am currently using three of your supplements: Exclzyme 2AF, Floracor-GI, and DigeSEB-GI. I started using your products...

- Karen Scheinberg, Brooklyn, NY

"…no hesitation recommending Exclzyme-2AF to both practitioners and clients"

“I have had the opportunity to use Exclzyme 2AF and to have some others with inflammation and pain issues use it....

- Gayle Eversole, DHom, PhD, MH, NP, ND, Garfield, WA

Supplement Facts

Serving Size: 1 Capsule
Servings Per Container: 90 or 200

Amount Per Serving:                         % DV

Vitamin C (as Calcium Ascorbate)       60 mg 100%
Vitamin B6 (as Pyridoxine HCl)           7.8 mg 390%
Calcium (as Calcium Ascorbate)         6.7 mg 0.67%

Folate (as Folic Acid)                        400 mcg 100%

Vitamin B12 (as Methylcobalamine) 100 mcg 1667%

Proprietary Enzyme Blend:                  500 mg *
Peptizyme SP EN (Enteric coated Serrapeptase), Proteases, Bromelain, Papain, Amylase, Amino Peptidase and Lipase

Proprietary Herbal Blend:                   175  mg *
Amla, Rutin, Grapeseed Extract, Boswellia and Tumeric

*Daily Value (DV) not established

Other ingredients:  Microcrystalline cellulose and cellulose (vegetarian capsule)

Directions: Take 1 to 2 capsules three times a day on an empty stomach. In three days, if desired benefit is not achieved, increase to 2 to 3 capsules three times a day. Take capsules at least 30 to 60 minutes before or 2 hours after a meal with 8 oz. of water. Store in cool, dry place with the lid tightly closed. Avoid excessive heat. Keep out of the reach of children.

Caution: If you are pregnant, nursing, taking any medication or under medical supervision, consult your doctor before use. Discontinue use and consult your doctor if any adverse reactions occur. Not intended for use by persons under the age of 18.

Free of pesticides, chemicals, preservatives, animal derivatives, dairy, lactose, yeast, fish or shellfish, peanuts, tree nuts, artificial sweeteners and colors.

All individual enzymes and probiotics are kosher-certified, and suitable for vegetarians and vegans.

Bioactive Protein Peptide System (BPPS®) is a proprietary manufacturing process featuring complementary bioactive peptides, ensuring greater enzyme stability, absorption and bio-availability.